Aggregation in Aqueous Solutions of Bovine Lens y-Crystallins: Special Role of ys
نویسندگان
چکیده
RESULTS. All of the y-crystallins studied formed large aggregates (or "megamers") in aqueous solutions. However, each protein differed in the relative rates of formation of megamers. ysCrystallin formed megamers much more slowly than y,,and yIVa-crystallin. In solutions containing mixtures of y,, and ys, and y,Va and ys, ys-crystallin significantly suppressed the aggregation of y,,and yIV:i-crystallin. Megamerization seemed to be associated with thiol oxidation in these proteins.
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